TB-500

Thymosin Beta-4 Fragment | Actin-Binding Peptide | Recovery Research

TB-500 is a synthetic peptide corresponding to the active fragment of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein found in virtually all nucleated mammalian cells. Tβ4 is one of the most abundant and evolutionarily conserved intracellular peptides identified in human biology.

Research into TB-500 focuses primarily on its role as an actin-sequestering peptide. Actin is a structural protein essential for cellular migration — a key process in tissue repair and immune response. Studies have examined TB-500's interactions with cell motility, angiogenic signalling, anti-inflammatory cytokine modulation, and anti-apoptotic pathways.

TB-500 is concentrated at injury sites in preclinical models, where it is released by platelets and white blood cells. Its small molecular size and lack of receptor specificity make it of interest to researchers studying systemic signalling dynamics. Unlike many growth factors, TB-500 is freely diffusible and not confined to receptor-bound localisation.

Supplied as lyophilised powder. Purity ≥99% by HPLC. Third-party Certificate of Analysis available — tested by Janoshik Analytical (Prague) and issued in Longev Peptides' name.

For research use only. Not for human consumption.